Inhibition of MRTF activation as a clinically achievable anti-fibrotic mechanism for pirfenidone.

Hsiao-Yen Ma,Jason A Vander Heiden,Salil Uttarwar,Ying Xi,Elsa-Noah N'Diaye,Ryan LaCanna,Patrick Caplazi,Sarah Gierke,John Moffat,Paul J Wolters,Ning Ding

The European respiratory journal（2023）

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摘要

Our results suggest MRTF signalling as a direct target for PFD and implicate that some of the anti-fibrotic effects of PFD may be due to MRTF inhibition in lung fibroblasts.

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关键词

mrtf activation,anti-fibrotic

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