The effects of dimethyl fumarate on cytoplasmic LPS-induced noncanonical pyroptosis in periodontal ligament fibroblasts and dental pulp cells.

Fan Gu, Hailin Wu,Zhuo Huang, Fei Wang,Ruihuan Yang,Zhuan Bian,Miao He

International endodontic journal（2023）

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摘要

The current study indicates that PDLFs and DPCs are more sensitive to cytoplasmic LPS-induced noncanonical pyroptosis and that DMF treatment blocks pyroptosis in LPS-transfected PDLFs and DPCs by targeting GSDMD, suggesting DMF might be a promising drug for the management of pulpitis and apical periodontitis.

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关键词

Dimethyl fumarate,dental pulp cells,periodontal ligament fibroblasts,pyroptosis

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