Environmental toxin chlorpyrifos induces liver injury by activating P53-mediated ferroptosis via GSDMD-mtROS.

Chenyang Han,Jian Sheng,Hongyan Pei,Yongjia Sheng,Jin Wang,Xiaohong Zhou,Wenyan Li,Chenxi Cao,Yi Yang

Ecotoxicology and environmental safety（2023）

引用 1|浏览3

暂无评分

摘要

CHI can bind to GSDMD to promote its cleavage, while NT-GSDMD can open mitochondrial membrane to promote the mtROS release. Cytoplasmic upregulation of ROS levels can facilitate the P53-mediated ferroptosis. GSDMD-mtROS is the primary mechanism whereby CHI induces ferroptosis in hepatocytes.

查看译文

关键词

Chlorpyrifos,Ferroptosis,GSDMD,Liver injury,Mitochondria,MtROS

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要