Knockdown of G Protein-coupled Estrogen Receptor 1 (GPER1) Enhances Tumor-supportive Properties in Cervical Carcinoma Cells.

Sophia Ruckriegl,Johanna Loris,Katsiaryna Wert,Gerd Bauerschmitz,Julia Gallwas,Carsten Gründker

Cancer genomics & proteomics（2023）

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摘要

GPER1 appears to be tumor suppressive in CC, as GPER1 knockdown provoked increased stem cell properties and increased migration/invasion. EMT also appears to be enhanced. Of interest is the increase in SERPINE1/PAI-1 expression after GPER1 knockdown.

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关键词

G-protein-coupled estrogen receptor 1,GPER1,SERPINE1/PAI-1,cervical carcinoma,tumor suppressor

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