Correlations between pathogenic variants in DNA repair genes and anticancer treatment efficacy in stage IV non‐small cell lung cancer: A large real‐world cohort and review of the literature

Itamar Averbuch,Roi Tschernichovsky,Oded Icht,Daniel A. Goldstein,Raz Mutai,Elizabeth Dudnik,Ofer Rotem,Nir Peled,Aaron M. Allen,Smadar Laufer‐Geva,Yael Goldberg,Alona Zer

Thoracic Cancer（2023）

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摘要

Our retrospective data suggest that in patients with stage 4 NSCLC, pathogenic variants in DDR pathway genes may be associated with higher efficacy of radiotherapy and immune checkpoint inhibitors (ICIs). This should be further explored prospectively.

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关键词

DNA damage repair mutations,immunotherapy,non-small cell lung cancer,platinum-based chemotherapy,radiotherapy

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