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Simple and Safe Digitoxin Dosing in Heart Failure Based on Data from the DIGIT-HF Trial.

CLINICAL RESEARCH IN CARDIOLOGY(2023)

Hannover Medical School

Cited 3|Views73
Abstract
The present study aimed to develop a simple dosing score when starting the cardiac glycoside digitoxin in heart failure with reduced ejection fraction (HFrEF) employing first data from the randomized, double-blinded DIGIT-HF trial. In DIGIT-HF, digitoxin was started with a dose of 0.07 mg once daily (o.d.) in all patients. For score derivation, 317 patients were analyzed who had been randomized to digitoxin. In these patients, after scheduled determination of serum levels at study week 6, the digitoxin dose had remained unchanged or had been reduced to 0.05 mg o.d. (97
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Key words
Cardiac glycosides,Digitoxin,Heart failure,Clinical trial,Dose titration
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