PARP Inhibitors for Prostate Cancer: Tangled up in PROfound and PROpel (and TALAPRO-2) Blues

Nick Beije,Wassim Abida,Emmanuel S. Antonarakis,Elena Castro,Ronald de Wit,Karim Fizazi,Silke Gillessen,Maha Hussain,Joaquin Mateo,Michael J. Morris,David Olmos,Oliver Sartor,Adam Sharp,Christopher J. Sweeney, Johann S. de Bono

European urology（2023）

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摘要

The combination of PARP and androgen receptor signalling inhibitors is best reserved for cases for which we expect an overall survival benefit on the basis of disease biology. The data to date should encourage us to perform more, not less, testing for DNA repair defects.

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关键词

Metastatic prostate cancer,Castration-resistant prostate cancer,PARP inhibitor,Androgen receptor signalling inhibitor

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