Cancer-associated fibroblasts are key determinants of cancer cell invasion in the earliest stage of colorectal cancer.

Hao Dang,Tom J Harryvan,Chen-Yi Liao,Erik H J Danen,Vienna N L N Spalburg,Szymon M Kielbasa,Hailiang Mei,Jelle J Goeman,Eveline S de Jonge-Muller,Stefanus G T Janson,Johan J van der Reijden,Stijn Crobach,James C H Hardwick,Jurjen J Boonstra,Noel F C C de Miranda,Lukas J A C Hawinkels

Cellular and molecular gastroenterology and hepatology（2023）

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摘要

Already in the earliest stage of CRC, cancer cell invasion is promoted by CAFs via direct interactions with epithelial cancer cells and stage-specific, Cathepsin H-dependent ECM remodeling.

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关键词

T1 colorectal cancer,cancer-associated fibroblast,tumor microenvironment

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