Degeneration of nigrostriatal dopaminergic neurons in the early to intermediate stage of dementia with Lewy bodies and Parkinson's disease.

Masato Okitsu,Keizo Sugaya,Yasuhiro Nakata,Tomoya Kawazoe,Jun Ikezawa,Ryoichi Okiyama,Kazushi Takahashi

Journal of the neurological sciences（2023）

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摘要

Loss of the soma and presynaptic terminals may occur independently in DLB with a large decrease in the presynaptic terminals. The close relationship observed between the degeneration of the soma and presynaptic terminals suggested that axon degeneration may dominate in PD.

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关键词

Dementia with Lewy bodies,Dopamine transporter scintigraphy,Neuromelanin-sensitive MRI,Nigrostriatal dopaminergic neuron,Parkinson's disease

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