CD137 signaling aggravates myocardial ischemia-reperfusion injury by inhibiting mitophagy mediated NLRP3 inflammasome activation

Guang-Yao ZANG,Qing YIN,Chen SHAO,Zhen SUN,Li-Li ZHANG,Yao XU,Li-Hua LI,Zhong-Qun WANG

Journal of Geriatric Cardiology（2023）

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摘要

Our results reveal that activating CD137 signaling aggravates myocardial IR injury by upregulating NLRP3 inflammasome activation via suppressing mitophagy and promoting mtROS generation.

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关键词

nlrp3 inflammasome activation,cd137 signaling,mitophagy,ischemia-reperfusion

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