Engineering Brain-Derived Neurotrophic Factor mRNA Delivery for the Treatment of Alzheimer’s Disease

Haoyuan Li,Yan Cao, Jingjing Ye,Zhipeng Yang,Qimingxing Chen, Xiaoqin Liu,Bohan Zhang,Jingwen Qiao,Qisheng Tang,Huiying Yang,Jianfeng Li,Zhifeng Shi,Ying Mao

Chemical Engineering Journal（2023）

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摘要

•New designed poly (β amino esters) (PBAE) nano-platform can achieve mRNA delivery to brain and spinal cord efficiently.•Stable mRNA secondary structures were engineered by AI and contributed to higher protein expressions.•3′UTR of mRNA was engineered to achieve neuron selective delivery with less side effects.

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关键词

Brain-derived neurotrophic factor, mRNA delivery, Poly (beta amino esters), 3'~UTR modification, Alzheimer 's disease

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