FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells.

Guohao Liu,Po Zhang,Sui Chen,Zirong Chen,Yanmei Qiu,Peng Peng,Wenda Huang,Fangling Cheng,Yang Zhang,Huan Li,Qungen Xiao,Feng Mao,Baofeng Wang,Xiaobing Jiang,Feng Wan,Dongsheng Guo,Xingjiang Yu

Neuro-oncology（2023）

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摘要

FAM129A and NICD1 provide a precise indicator for identifying tumor margins and aiding prognosis. Targeting them may provide a significantly therapeutic strategy for GSCs.

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关键词

FAM129A,NICD,Notch pathway,glioma stem cell,tumor invasion

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