Comparative genomics between matched solid and lepidic portions of semi-solid lung adenocarcinomas

•Semi-solid lung lesions had excellent survival after surgical resection.•This study showed lower EGFR mutation rates than studies of Asian populations.•Driver mutations found in both the lepidic and solid portions of the same lesion.•Microarray showed similar gene expression between lepidic and solid areas.•Several genes identified with increased expression may be potential biomarkers.