Old T cells pollute with mito-litter

Manuel M. Gómez de las Heras,María Mittelbrunn

Nature Aging（2023）

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摘要

The mysteries behind immune aging and its related inflammation are being unmasked. Jin et al. reveal that the defective turnover of damaged mitochondria in CD4 + T cells from older individuals results in the exacerbated secretion of mitochondrial DNA, which fuels inflammaging and impairs immune responses.

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关键词

Inflammation,Lymphocytes,Life Sciences,general

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