Methotrexate as a corticosteroid-sparing agent in leprosy reactions: A French multicenter retrospective study.

Léa Jaume,Estelle Hau,Gentiane Monsel,Antoine Mahé,Antoine Bertolotti,Antoine Petit, Britney Le, Marie Chauveau, Elisabeth Duhamel,Thierry Maisonobe,Martine Bagot,Jean-David Bouaziz,Faïza Mougari,Emmanuelle Cambau,Marie Jachiet

PLoS neglected tropical diseases（2023）

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摘要

MTX seems to be an effective alternative treatment in LRs, allowing for GCs-sparing with a good safety profile. Furthermore, early introduction during LRs may lead to a better therapeutic response. However, its efficacy seems to suggest prolonged therapy to prevent recurrence.

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