Elevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals.

Juwon Park,Logan S Dean,Boonyanudh Jiyarom,Louie Mar Gangcuangco,Parthav Shah,Thomas Awamura,Lauren L Ching,Vivek R Nerurkar,Dominic C Chow,Fritzie Igno,Cecilia M Shikuma,Gehan Devendra

Frontiers in immunology（2023）

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摘要

This study present evidence that COVID convalescents exhibit monocyte alteration beyond the acute COVID-19 infection period even in convalescents with no residual symptoms. Further, the results suggest that monocyte alteration and increased activated monocyte subsets may impact pulmonary function in COVID-19 convalescents. This observation will aid in understanding the immunopathologic feature of pulmonary PASC development, resolution, and subsequent therapeutic interventions.

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关键词

CD169,Long-COVID,SARS-CoV-2,monocytes,post-acute sequalae of SARS-CoV-2 infection,pulmonary sequelae

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