Sensory innervation of the lumbar 5/6 intervertebral disk in mice.

Lunhao Chen,Xuan Lu,Qianjun Jin,Zhihua Gao,Yue Wang

Frontiers in neurology（2023）

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摘要

Intervertebral disks were innervated by multiple types of nerve fibers in mice, including Aβ, Aδ, C, and proprioceptive fibers. No sympathetic nerve fibers were found in AF. The nerve network of the L5/6 disk in mice was multi-segmentally innervated by the Th13-L6 DRGs (mainly L1 and L5 DRGs). Our results may serve as a reference for preclinical studies of discogenic pain in mice.

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关键词

dorsal root ganglia (DRG),lumbar intervertebral disk,nerve terminal,neural pathways,neuron,retrogade tracing

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