CsHscB Derived from a Liver Fluke Clonorchis Sinensis Ameliorates Cholestatic Hepatic Fibrosis in a Mouse Model of Sclerosing Cholangitis.

Qian Yu,Stephane Koda,Na Xu,Jing Li,Jian-Ling Wang,Man Liu,Ji-Xin Liu,Yu Zhang,Hui-Min Yang,Bei-Bei Zhang,Xiang-Yang Li,Xiao-Cui Li,Ren-Xian Tang,Kui-Yang Zheng,Chao Yan

Current molecular medicine（2023）

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摘要

Overall, our data show that rCsHscB attenuates the progression of cholestatic fibrosis induced by DDC and supports the potential for manipulating the parasite-derived molecule to treat certain immune-mediated disorders.

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关键词

Cholestatic liver fibrosis,Clonorchis sinensis,DDC,PPAR-?,Protein CsHscB

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