Exploiting metabolic vulnerabilities in breast cancers with NF1 loss

Cell Reports Medicine（2023）

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摘要

Auf der Maur et al. identify neurofibromin 1 (NF1) loss as a mechanism of resistance to PI3K inhibitor in breast cancer cells. NF1 loss leads to enhanced glycolysis, which may be targeted with the antioxidant N-acetyl cysteine (NAC).

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