Repeated gentle handling or maternal deprivation during the neonatal stage increases adult male rats' baseline orofacial pain responsiveness.

Archives of oral biology(2023)

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摘要
In this study neonatal gentle handling or MD treatment increased orofacial pain in adulthood, showing early life experiences permanent effects on the development of trigeminal circuits in the brain.
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关键词
Dental pulp,Headache,Maternal deprivation,Neonatal handling,Nociception,Rats
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