Cognitive Function in People With Familial Risk of Depression.

Breda Cullen,Marc J Gameroff,Joey Ward,Mark E S Bailey,Donald M Lyall,Laura M Lyall,Niamh MacSweeney,Eleanor Murphy,Natasha Sangha,Xueyi Shen,Rona J Strawbridge,Milenna T van Dijk,Xingxing Zhu,Daniel J Smith,Ardesheer Talati,Heather C Whalley,Jonathan Cavanagh,Myrna M Weissman

JAMA psychiatry（2023）

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摘要

In this study, whether assessed by family history or genetic data, depression in prior generations was associated with lower cognitive performance in offspring. There are opportunities to generate hypotheses about how this arises through genetic and environmental determinants, moderators of brain development and brain aging, and potentially modifiable social and lifestyle factors across the life span.

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