Novel (sulfated) thyroid hormone transporters in the solute carrier 22 family.

Zhongli Chen,Robin P Peeters,Wesley Flach,Linda J de Rooij, Sena Yildiz,Alexander Teumer,Matthias Nauck,Rosalie B T M Sterenborg,Joost H W Rutten,Marco Medici,W Edward Visser,Marcel E Meima

European thyroid journal（2023）

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摘要

Our results demonstrated that members of the OAT clade of the SLC22 family constitute a novel, evolutionary conserved group of transporters for (sulfated) iodothyronines. Future studies should reveal the relevance of these transporters in TH homeostasis and physiology.

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thyroid hormone transporters,solute carrier

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