Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression.

Daoyan Wei,Liang Wang,Yi Liu,Margarete A Hafley,Lin Tan,Philip L Lorenzi,Peiying Yang,Xiangsheng Zuo,Robert S Bresalier

Digestive diseases and sciences（2023）

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摘要

These findings demonstrate a previously unidentified vitamin D/VDR-MUC1 signaling axis involved in the regulation of gemcitabine resistance in PDA and suggests that combinational therapies that include targeted activation of vitamin D/VDR signaling may improve the outcomes of patients with PDA.

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关键词

Gemcitabine resistance,MUC1,Pancreatic cancer,VDR

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