Bias in observational studies on the effectiveness of in hospital use of hydroxychloroquine in COVID-19.

M Mirjam Hempenius, S H Sophie Bots,R H H Rolf Groenwold,A Ton de Boer,O H Olaf Klungel,H Helga Gardarsdottir

Pharmacoepidemiology and drug safety（2023）

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摘要

Overall, the quality of observational HCQ studies was heterogeneous. Synthesis of evidence of effectiveness of HCQ in COVID-19 should focus on RCTs and carefully consider the added value and quality of observational evidence.

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COVID-19,bias,efficacy,hydroxychloroquine,methodology,pharmacoepidemiology,post market,regulatory

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