Trial of thromboxane receptor inhibition with ifetroban: TP receptors regulate eicosanoid homeostasis in aspirin-exacerbated respiratory disease.

Tanya M Laidlaw,Kathleen M Buchheit,Katherine N Cahill,Jonathan Hacker, Laura Cho,Jing Cui,Chunli Feng, Chongjia Chen, Meghan Le,Elliot Israel,Joshua Boyce

The Journal of allergy and clinical immunology（2023）

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摘要

TP inhibition with ifetroban is well tolerated in AERD patients but may worsen their aspirin-induced reactions, likely due to ifetroban's inhibition of PGE and increase of cysteinyl leukotrienes.

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关键词

AERD,Aspirin-exacerbated respiratory disease,Samter's triad,ifetroban,mast cell,platelet,thromboxane receptor

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