Ethanol-induced suppression of GIRK-dependent signaling in the basal amygdala.

Ezequiel Marron Fernandez de Velasco,Megan E Tipps,Bushra Haider, Anna Souders,Carolina Aguado,Timothy R Rose,Baovi N Vo,Margot C DeBaker,Rafael Luján,Kevin Wickman

Biological psychiatry（2023）

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摘要

The ethanol-induced suppression of GIRK-dependent signaling in BA principal neurons contributes to some of the mood-related behaviors associated with ethanol withdrawal in mice. Approaches designed to prevent this neuroadaptation and/or strengthen GIRK-dependent signaling may prove useful for treatment of AUD.

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关键词

Alcohol,GABA(B) receptor,Kir3,behavior,neuroadaptation

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