Protease activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.

Tanvi Rudran,Silvio Antoniak,Matthew J Flick,Mark H Ginsberg,Alisa S Wolberg,Wolfgang Bergmeier,Robert H Lee

Journal of thrombosis and haemostasis : JTH（2023）

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摘要

Our results demonstrate that standard TEG is not sensitive to platelet signaling pathways critical for integrin inside-out activation and platelet hemostatic function. Furthermore, we provide first evidence that PARs and GPVI play redundant roles in platelet-mediated clot contraction in TEG.

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关键词

Thromboelastography,bleeding,blood platelets,fibrin,protease-activated receptor

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