Rustrela Virus as Putative Cause of Nonsuppurative Meningoencephalitis in Lions

Madeleine de le Roi,Christina Puff,Peter Wohlsein,Florian Pfaff,Martin Beer,Wolfgang Baumgärtner,Dennis Rubbenstroth

Emerging Infectious Diseases（2023）

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摘要

Retrospective investigation of archived tissue samples from 3 lions displaying nonsuppurative meningoencephalitis and vasculitis led to the detection of rustrela virus (RusV). We confirmed RusV antigen and RNA in cortical neurons, axons, astrocytes and Purkinje cells by reverse transcription quantitative PCR, immunohistochemistry, and in situ hybridization.

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关键词

rustrela virus,Rubivirus,Rubivirus strelense,lions,viruses,meningoencephalitis

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