Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors.

Eleonora Khlebus,Veena K Vuttaradhi, Thomas Welte,Namrata Khurana,Joseph Celestino,Hannah C Beird,Curtis Gumbs,Latasha Little,Alejandra Flores Legarreta,Bryan M Fellman,Tri Nguyen,Barrett Lawson,Sammy Ferri-Borgogno,Samuel C Mok,Russell R Broaddus,David M Gershenson,P Andrew Futreal,R Tyler Hillman

Molecular cancer research : MCR（2023）

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摘要

Recurrent aGCTs exhibit alterations in hormone pathway gene expression as well as decreased infiltration of cancer-associated fibroblasts, suggesting dual roles for hormonal signaling and TME remodeling underpinning disease relapse.

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tumor,cell

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