Remote Electronic Effect of Chiral N-Heterocyclic Carbene Catalyst on an Asymmetric Benzoin Reaction.

Tsubasa Inokuma, Kentaro Hashimoto,Tatsuya Fujiwara,Chunzhao Sun,Satoru Kuwano,Ken-Ichi Yamada

Chemistry (Weinheim an der Bergstrasse, Germany)（2023）

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摘要

A remote electronic effect of chiral aminoindanol-derived N-heterocyclic carbene catalyst on an asymmetric benzoin reaction was investigated. The catalyst bearing remote electron-withdrawing substituents increased enantioselectivity of the reaction at the cost of the reaction rate. DFT calculations rationalized the increased enantioselectivity.

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关键词

N-heterocyclic carbene,asymmetric reaction,benzoin reaction,organocatalysis

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