New steroidal saponins from the roots of Paris verticillata

Four new polyhydroxylated steroidal saponins, parisverticillatosides A-D (1–4), together with four known spirostanol saponins (5–8) were isolated from the roots of Paris verticillata. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidences. The discovery of the new compounds 1–4 extended the diversity and complexity of this spirostanol saponin family. The saponins 5 and 6 exhibited cytotoxicities against two human glioma cell lines.