iNOS expressing macrophages co-localize with nitrotyrosine staining after myocardial infarction in humans.

Verena Wilmes,Ivan M Kur,Andreas Weigert,Marcel A Verhoff,Elise Gradhand,Silke Kauferstein

Frontiers in cardiovascular medicine（2023）

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摘要

These results indicate that, unexpectedly, resident macrophages are the main source of iNOS expression in postmortem human MI hearts. The peak of NT positive cells within 10-15 µm of iNOS+ cells suggest an iNOS dependent level of NT and therefore iNOS dependent oxidative stress. Our results contribute to understanding the role of iNOS in human MI.

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关键词

iNOS,iNOS expressing macrophages,inflammation,macrophage populations,myocardial Infarction,oxidative stress

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