Bioinformatics-integrated screening of systemic sclerosis-specific expressed markers to identify therapeutic targets.

Jiahui Jin,Yifan Liu,Qinyu Tang, Xin Yan,Miao Jiang,Xu Zhao,Jie Chen,Caixia Jin,Qingjian Ou,Jingjun Zhao

Frontiers in immunology（2023）

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摘要

This study revealed tissue-specific expressed genes, SERPINE1, CCL2, IL6, and ISG15, as effective biomarkers and provided new insight into the mechanisms of SSc. Potential RNA regulatory pathways, including MALAT1-miR-206-CCL2, let-7a-5p-IL6, and miR-196a-5p-SERPINE1, contribute to our knowledge of SSc. Furthermore, the analysis of drug-hub gene interactions predicted TIPLASININ, CARLUMAB and BINDARIT as candidate drugs for SSc.

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关键词

RNA regulatory pathway,biomarkers,drug-gene interaction,systemic sclerosis,tissue-specific expressed genes

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