Identification and validation of hub genes in drug induced acute kidney injury basing on integrated transcriptomic analysis.

Yi-Xuan Deng,Kun Liu,Qun-Xiang Qiu, Zhi-Yao Tang,Rui-Man Que,Dian-Ke Li,Xu-Rui Gu,Guang-Liang Zhou,Yi-Feng Wu,Ling-Yun Zhou,Wen-Jun Yin,Xiao-Cong Zuo

Frontiers in immunology（2023）

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摘要

The immune system and inflammation are key factors in DI-AKI. We discovered the immunological and inflammatory-related genes TLR4, AOC3, IRF4, and TNFAIP6, which may be promising specific biomarkers and essential hub genes for the prevention and identification of DI-AKI.

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关键词

Limma package,drug-induced acute kidney injury,hub genes,in vitro and in vivo validation,weighted gene co-expression network analysis

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