Three-dimensional and single-cell sequencing of liver cancer reveals comprehensive host-virus interactions in HBV infection.

Mengbiao Guo,Zhicheng Yao,Chen Jiang,Zhou Songyang,Lian Gan,Yuanyan Xiong

Frontiers in immunology（2023）

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摘要

Our work promotes mechanistic understanding of HBV infection and host-virus interactions related to liver diseases that affect billions of people worldwide. Our findings may also have implications for novel immunotherapeutic strategies targeting HBV infection.

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关键词

HBV,Hi-C,TAD and A/B compartments,host-virus interaction,liver cancer,single cell sequencing,structural variation (SV),transposable element (TE)

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