Western diet unmasks transient low-level vinyl chloride-induced tumorigenesis; potential role of the (epi-)transcriptome.

Silvia Liu,Liqing He,Olivia B Bannister,Jiang Li,Regina D Schnegelberger,Charis-Marie Vanderpuye,Andrew D Althouse,Francisco J Schopfer,Banrida Wahlang,Matthew C Cave,Satdarshan P Monga,Xiang Zhang,Gavin E Arteel,Juliane I Beier

Toxicology and applied pharmacology（2023）

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摘要

These data indicate that VC sensitizes the liver to other stressors (e.g., WD), resulting in enhanced tumorigenesis. These data raise concerns about potential interactions between VC exposure and WD. It also emphasizes that current safety restrictions may be insufficient to account for other factors that can influence hepatotoxicity.

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关键词

Chloroethylene,Exposure,Hepatocellular cancer,Liver Disease,Volatile Organic Compound

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