SARS-CoV-2 variant-dependent inflammasome activation.

Elisa Teyssou,Stéphane Marot,Adélie Gothland,Isabelle Malet,Karen Zafilaza,Valentin Leducq,Théophile Cocherie,Eve Todesco,Cathia Soulié,Anne-Geneviève Marcelin,Vincent Calvez

The Journal of infection（2023）

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摘要

•SARS-CoV-2 infection led to IL-1β secretion in THP-1 cells.•IL-1β secretion was activated in a SARS-CoV-2 variants-dependent manner.•Omicron BA.1 led to the stronger IL-1β secretion.•Omicron BA.1 was more recognized by the innate immune cells than other variants.

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sars-cov,variant-dependent

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