Long-Duration Response to Levodopa, Motor Learning, and Neuroplasticity in Early Parkinson's Disease.

Giorgia Sciacca,Giovanni Mostile,Ivano Disilvestro,Giulia Donzuso,Alessandra Nicoletti,Mario Zappia

Movement disorders : official journal of the Movement Disorder Society（2023）

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摘要

The achievement of a sustained LDR may act synergistically with motor learning to induce adaptive changes in neuroplasticity in basal ganglia and cortical networks. Our findings support LDR as a pharmacological outcome possibly facilitating the action of motor learning on neuroplasticity in early PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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关键词

Parkinson's disease,levodopa,long-duration response,motor learning,treatment

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