A bioorthogonal antibody-based chemically-induced-dimerization switch for therapeutic application
bioRxiv (Cold Spring Harbor Laboratory)(2023)
摘要
We present the Indinavir Ligand Induced Transient Engagement switch (IDV LITE Switch), a fully synthetic Chemically Induced Dimerization (CID) system wherein two humanized antibody fragments are heterodimerized by the antiviral drug indinavir. The IDV LITE Switch represents the first CID system made from fully humanized protein components and dimerized by a clinically approved small molecule drug lacking a mammalian target, making it an ideal bioorthogonal molecular switch for application in small-molecule controlled therapeutics.
### Competing Interest Statement
All authors are former employees and equity holders in Soteria Biotherapeutics, Inc..
更多查看译文
关键词
antibody-based,chemically-induced-dimerization
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要