Isolation and structure determination of allopteridic acids A–C and allokutzmicin from an unexplored actinomycete of the genus Allokutzneria
The Journal of antibiotics(2023)
摘要
Two classes of new polyketides, allopteridic acids A–C ( 1 – 3 ) and allokutzmicin ( 4 ), were isolated from the culture extract of an actinomycete of the genus Allokutzneria . The structures of 1 – 4 were elucidated through the interpretation of NMR and MS analytical data. Compounds 1 – 3 possess the same carbon skeleton with pteridic acids but their monocyclic core structures are distinct from the spiro-bicyclic acetal structures of pteridic acids. Compound 4 is a linear polyketide of an unprecedented class, featured by a guanidino-terminus and an epoxide modification. Compounds 1 – 3 promoted the root elongation of germinated lettuce seeds by ca . 10–40% at 1~10 μM whereas 4 retarded the seed growth. Compound 4 exhibited weak antimicrobial activity against Candida albicans with MIC 25 μg mL −1 .
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关键词
Biochemistry,Natural products,Life Sciences,general,Microbiology,Medicinal Chemistry,Organic Chemistry,Bacteriology,Bioorganic Chemistry
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