The Alzheimer's disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta‐mediated pathology

Joshua D. Samuels, Katelyn A. Moore,Hannah E. Ennerfelt,Alexis M. Johnson,Adeline E. Walsh,Richard J. Price,John R. Lukens

Alzheimer's & Dementia（2023）

引用 4|浏览16

暂无评分

摘要

Inpp5d deficiency in microglia increases plaque-associated microglia numbers. Loss of Inpp5d induces activation and phagocytosis transcriptional pathways. Plaque encapsulation and engulfment by microglia are enhanced with Inpp5d deletion. Genetic ablation of Inpp5d protects against plaque-induced neuronal dystrophy.

查看译文

关键词

Alzheimer's disease,INPP5D,SHIP-1,amyloid beta,amyloidosis,disease-associated microglia,microglia,neurodegenerative disease,neuroimmunology

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要