Farnesoid X receptor alpha ligands inhibit HDV in vitro replication and virion infectivity.

Anne-Flore Legrand,Julie Lucifora,Benoît Lacombe,Camille Ménard,Maud Michelet,Adrien Foca, Pauline Abrial,Anna Salvetti,Michel Rivoire,Vincent Lotteau,David Durantel,Patrice André,Christophe Ramière

Hepatology communications（2023）

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摘要

FXR ligands both inhibit directly (ie, independently of anti-HBV activity) and indirectly (ie, dependently of anti-HBV activity) the replication, secretion, and infectivity of HDV. The overall anti-HDV activity was superior to that obtained with interferon-α, highlighting the therapeutic potential of FXR ligands in HDV-infected patients.

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