Mediation analysis unveils a carcinogenic effect of ADH1B rs1229984 through mechanisms other than change in drinking intensity: oesophageal cancer case-control study.

Yukihiro Sugimoto,Yuriko N Koyanagi,Yukino Kawakatsu,Isao Oze,Yukari Taniyama,Yumiko Kasugai,Tsutomu Tanaka,Tetsuya Abe,Masahiro Tajika,Yasuhiro Shimizu,Hidemi Ito,Kenji Wakai,Keitaro Matsuo

Japanese journal of clinical oncology（2023）

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摘要

These results indicate that ADH1B Arg allele contributes to oesophageal cancer risk by slowing alcohol breakdown, in addition to its effect on the amount of alcohol consumed.

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关键词

alcohol consumption,alcohol dehydrogenase 1B,aldehyde dehydrogenase 2,mediation analysis,oesophageal cancer

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