Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough.

Brigit High,Marie E Jetté,Mei Li,Vijay R Ramakrishnan,Matthew Clary,Jeremy Prager,Julia Draf,Thomas Hummel,Thomas E Finger

ERJ open research（2023）

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摘要

These findings suggest that for most humans, unlike mice, taste buds are innervated by nerve fibres predominantly expressing only P2X3 homomeric receptors and not P2X2/P2X3 heteromers. Thus, antagonists specific for P2X3 homomeric receptors might not be spared from affecting taste function in RCC/UCC patients.

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关键词

human taste nerves,p2x receptor composition,chronic cough

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