Comprehensive clinical pharmacology characterization of AZD4635 in healthy participants to support dosing considerations.

Ganesh Moorthy,Gayle Pageau Pouliot,Lorraine Graham,Elizabeth Pilling,Lindsey Jung, Rachael Alcobi, Yali Zhu,Yan Li,Sharan Sidhu,Pablo Forte,Ganesh Mugundu

British journal of clinical pharmacology（2023）

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摘要

The high-fat meal reduced the rate but not the extent of AZD4635 absorption. Effect of gastric pH on AZD4635 was minimal. Smoking had no effect on the exposure (C and AUC ) of AZD4635, while fluvoxamine increased AZD4635 C and total exposure. No new safety concerns were identified.

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关键词

A2AR antagonist,AZD4635,healthy participants,pharmacokinetics,relative bioavailability

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