Retinal Vascular Oxygen Saturation in Adults With Anisometropia

Purpose: This study aimed to examine the differences of retinal oxygen saturation between the paired eyes in anisometropia and to further explore the relation between retinal oxygenation and myopia.Methods: This was an observational cross-sectional study, with 124 adults with anisometropia included. According to the interocular differences in spherical equiva-lent (SE), individuals with a difference >3.0 D belonged to the ASE > 3.0 D group, and those with a difference >1.5 D and <3.0 D belonged to the ASE <3.0 D group. The ASE > 3.0 D group contained 61, and the ASE < 3.0 D group contained 64. All were performed examinations of retinal oximetry, SE, axial length (AL), intraocular pressure, central corneal thickness and average keratometry.Results: The median SE and AL were -5.06 (-7.22 & SIM; -3.41) D and 25.54 (24.73 & SIM; 26.62) mm in the "ASE < 3 D" group and -4.25 (-6.88 & SIM; -2.09) D and 25.52 (24.49 & SIM; 26.45) mm in the other group. The retinal arterial oxygen saturation (SaO2) was 93.97% & PLUSMN; 1.26% in the less myopic eyes and 93.18% & PLUSMN; 1.53% (P < 0.001) in the more myopic eyes. In multivariate analyses, SE and AL were both significantly associated with the SaO2.Conclusions: The SaO2 between anisometropic myopic eyes was different, and it was associated with SE and AL.Translational Relevance: This study demonstrates a relationship between myopia and retinal vascular oxygenation through a novel retinal oximeter.