Molecular signature of methotrexate response among rheumatoid arthritis patients.

Boel Brynedal,Niyaz Yoosuf, Tinna Bjorg Ulfarsdottir,Daniel Ziemek,Mateusz Maciejewski,Lasse Folkersen,Helga Westerlind,Malin Müller,Peter Sahlström,Scott A Jelinsky,Aase Hensvold,Leonid Padyukov, Nancy Vivar Pomiano,Anca Catrina,Lars Klareskog,Louise Berg

Frontiers in medicine（2023）

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摘要

We conclude that a deep molecular and cellular phenotyping of peripheral blood cells in RA patients treated with methotrexate can reveal previously not recognized differences between responders and non-responders during 3 months of treatment with MTX. This may contribute to the understanding of MTX mode of action and explain non-responsiveness to MTX therapy.

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关键词

flow cytometry,gene expression,methotrexate,plasma proteins,rheumatoid anhritis,transcriptomics,treatment response

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