Effects of Alkoxy Chain Length and 1-Hydroxy Group on Anticolorectal Cancer Activity of 2-Bromoalkoxyanthraquinones.

Nurhaliza Wati Mekzali,Cheok Wui Chee,Iskandar Abdullah,Yean Kee Lee,Nurshamimi Nor Rashid,Vannajan Sanghiran Lee,Rozana Othman,Najihah Mohd Hashim,Chin Fei Chee

Medicinal chemistry (Shariqah (United Arab Emirates))（2023）

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摘要

This work highlights the potential of the 1-hydroxy group and short alkoxy chain on anticolorectal cancer activity of 2-bromoalkoxyanthraquinones. Further optimisation may be warranted for compound 6b as a therapeutic agent against colorectal cancer.

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关键词

2-hydroxyanthraquinone,Alizarin,alkylation,antiproliferation,colorectal cancer,in silico,side chaiAlizarin,side chain

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