Human brain white matter function analysis based on functional gradient

In this work, we estimated the functional gradients of whole-brain white matter (WM) based on a new diffusion map embedding algorithm and resting-state functional magnetic resonance imaging (rs-fMRI) signals of WM. We discussed the symmetry of the functional hierarchy of the left and right brain in healthy individuals using the whole brain WM principal functional gradient, which also included separate studies for different genders. Secondly, we studied and analyzed the distribution of functional gradient values in the spatial structure of the corpus callosum (CC) and found that there is not completely a simple one-to-one correspondence between structure and function, which may be related to the tightness of their internal structural connectivity.