One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel-Crafts Alkylation of gamma-Hydroxybutyrolactams

Vladimir T. Abaev,Nicolai A. Aksenov,Dmitrii A. Aksenov,Elena V. Aleksandrova,Alesia S. Akulova,Igor A. Kurenkov,Alexander V. Leontiev,Alexander V. Aksenov

Molecules（2023）

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摘要

The Friedel-Crafts reaction of novel 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones was used for low cost, one-pot preparation of polycyclic indole derivatives structurally similar to Ergot alkaloids.

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关键词

polycyclic indoles,intramolecular Friedel–Crafts reaction,cascade transformations

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